You start on the bridge - when you try to leave the screen, Largo will steal your money (no matter what you say!). Once he's gone, pick up the shovel (from the sign), and exit to the right. Go to thw swamp area, and use the coffin. Keep rowing to the right, until you enter the voodoo woman's house. Pick up the string from the table in the first room, and then look at the jars until you find the "Ash-2-Life". Try to pick it up, and you will start talking to the voodoo woman. Also ask her about Largo, to get the shopping list. Use the coffin again to return to shore.
Walk to the cemetery, and go to the top of the hill. Use the shovel of Largo's grandfather's grave (on the left). Next, go to the beach, and pick up the stick. Go back to town, and enter Wally's place (second door from the right). Talk to Wally and take a sheet of paper from the pile. When Wally puts down his monocle, pick it up. Go outside and swing through the left window on the ship (at the bottomof the screen). Pick up the knife and leave again.
Go into the ship on the far left and set Pegbiter loose with your knife. Pick up the bowl (to get the cheese squigglies) and go into Largo's room on the left. Steal his toupee off the styrofoam head and leave again. Go up to the group of pirates to the north, and pick up the bucket. Take a look at the rat - you need to catch it. Open the box, use the stick with the box, use the string with the stick, and use the cheese squigglies with the box. Leave the screen and come back, and the rat should be eating. Pull the string, then open the box and take the rat.
Walk down through the hatch near the window you jumped through earlier, and talk to the barkeeper. Keep asking for a drink until Largo comes in and spits on the wall. Use the blank sheet of paper with the dripping spit. Go back into the kitchen via the window and put the rat in the vichyssoise (soup). Go back into the bar and ask for some soup. Eventually turn the soup down, but take the job. After you get paid, bail out the window.
Leave town and go to the swamp. Fill the bucket with mud and head back to town. Go into Largo's room, close the door, use the bucket with the door and hide behind the dressing screen. Follow Largo to the laundry and watch the conversation. Go back to his room, close the door and take the ticket. Give the laundry guy the ticket and get the bra?! Head back to the voodoo woman and give her the four items (toupee, bone, bra and spit). Get the voodoo doll and head back to Largo's room. When he tries to throw you out, use the pins on the doll.
Go to the peninsula and talk to the captain. Give him the monocle (close enough to a necklace) to end part one.
Sail to Phatt Island (while you are on the boat, pick up some parrot chow). When you arrive on Phatt Island you will be arrested and thrown in jail (eventually). Get the stick from under the mattress, and use the stick on the bone. Pick up the bone and give it to the dog. Get the key and use it on the door to free yourself. Take and then open both envelopes from the shelves before leaving.
Talk to the fisherman (to the right) and brag about your fishing skills. Head into the library and open the model lighthouse. Take the lens and then apply for a library card. Use the card catalog, and find the names of three books. The first is under "D" for Disasters and is about shipwrecks. The second is under "R" for Recipes. It doesn't matter what the third one is. After remembering all three names, go to the librarian and ask for them. Walk to the "path" off in the distance, and off to Phatt Mansion.
Enter the mansion and try to walk up the stairs. Tell the guard you are Guybrush's cousin, and that there is a fire in the kitchen. Go up the stairs, and swap the third book (whatever it was) with the book on Phatt boy's belly. Head back to the wharf and into the alley to the left of the library. Watch the guy win, and quickly follow him into the second alley. When he leaves, knock on the door and ask for the next roulette number. Watch for the number of fingers he holds up the first time - this is the answer to his question. Answer correctly three times to get the next number. Head back to the first alley and win, then get the next number, etc. until you clean them out. Go back to the ship and sail to Booty Island.
Go into the small shop to your left, and buy the sign about the parrot, the ship's horn, a hub cap, a pirate hat, the saw, an elvis plate and a feather pen. Put the parrot chow on the hook the sign was using, and buy the parrot's mirror. Look at the map piece and ask about trade-ins. Leave and enter the costume shop. Give the Mardi Gras ticket to the guy in the shop, to get your costume, then get a flyer from Kate (outside again). On the map screen, select the mansion.
On your way, you will have to show your invitation and put on your costume. Go around the back of the mansion and push the garbage cans. Run away from the angry cook and do a complete lap of the house. Go into the kitchen and grab a fish from the pot. Now leave and enter the mansion through the front door. Take the piece of map from the painting on the far left of the room, and leave. You will be stopped by the gardener, and get taken upstairs. Be nice to Elaine, and leave the mansion. Try to pick up the map piece and it will fly away. Go back inside and upstairs, and take the oar from above Elaine's bed. Go outside and pick up the dog (literally).
Go back to Phatt island and give the fish to the fisherman. After getting the fishing pole go back to Booty island and go to the cliff. Use the fishing pole to try to get the map piece, but a bird will steal it. Follow the bird to the big tree. Place the oar in the second hole, and walk on the existing plank, followed by the oar. After your weird dream, pick up the broken oar, and return to Scabb Island.
Enter the first door from the right - the woodsmith's place. Give the broken oar to the woodsmith and he will fix it for you. Go back and see Wally again, and give him the lighthouse lens. Next, go back to the bar and order one of each type of colored drink (and you will get a free crazy straw). Make sure you also ask for some near-grog at some stage. Use the banana on the metronome (on the piano) and then take Jojo the monkey. Go up and see the group of three pirates (next to the laundry guy. Saw off the pirate's peg-leg, and head over to the woodsmith's workshop again. Get the hammer and nails, and then head back to Booty Island.
Go into Stan's shop. While he's trying to give you a deal, he'll get inside a coffin - close the coffin and keep him inside by using the hammer and nails. (Try ringing the bell while he's shut in there for a laugh!) Take the crypt key from behind the counter. Go over to the spit contest (to the right of Stan's). Use the ship horn to get rid of the spitmaster, and then pick up the flag. Mix the yellow and blue drinks, and then drink the green mixture with the crazy straw. Talk to the spitmaster and enter the contest. Watch the sash on the waist of the right contestant and when it blows in the wind, spit. You should win the contest and get a plaque. Head back to the antique store. Convince the shopkeeper to give you 6000 pieces of eight for the plaque.
Read the book about the shipwrecks/disasters and note the coordinates where the Mad Monkey capsized. Charter a ship from Kate, and move the pointer to the coordinates shown in the book. When you get there on the boat, dive down into the sea and pick up the figure-head. It's too heavy for you to carry to the surface, so swim to the left and pull the rope. Back on Booty Island, ask Kate for some near-grog, but she won't give you any. Back at the antique shop, swap the figurehead for the map piece. Go back to the big tree, and use the reinforced oar with the second hole. Walk on the plank, then the oar. Pick up the plank and place it in the third hole, etc. Take the telescope from the topmost treehouse, and then go into the bottom treehouse. Use the dog on the pile of maps to locate the right one. Head back to Scabb Island.
Go to the cemetery and use the crypt key on the crypt (on the right). Read the book of Pirate Quotations, and then look at the bottom, centre coffin. Open the coffin and pick up the ashes. Go back to the voodoo woman and give her the ashes. When she forgets the recipe, give her the Hex book and get the potion. Return to the crypt and use the potion on the ashes. Talk to the dead guy and get the key to his Weenie Shack. Go to the beach and use the key on the shack door. Turn the burners off and return to the crypt. Use the potion again and he will give you the third part of the map. Return yet again to Phatt Island.
Place Kate's leaflet on top of your wanted poster and walk out of town. When Kate gets arrested, go and visit her in jail. Take her envelope and open it. Go to the waterfall (from the island map). Walk to the top of the hill and use Jojo the monkey on the pump. Walk through the "newly discovered gaping hole" to appear on the small island. Enter the cottage and agree to engage in a drinking contest with the old man. He will bring you a drink and leave again to get his own. While he's gone, pick up the mug and empty it into the tree. Pour the near-grog into your mug - you will both drink and he will pass out. Place your mirror in the mirror frame on the back wall, and open the shutters on the right-hand window. Go outside and walk over to the ugly statue. Read the plaque and then put the telescope in the statue's hand. After the secret brick is revealed, go back into the cottage and pull it. Take the map piece from the skeleton and go through the hole in the floor. Return to Dread's ship and go to Scabb Island.
Give the map pieces to Wally, and while he works, go and pick up his love potion from the voodoo woman. On the way back to Wally, open the bag to find the bomb and matches. Read the message scratched into Wally's table, and go back to the swamp. Get into the crate, and you will get carried off to LeChuck's Fortress.
In the fortress, walk to the right, up the stairs and through the doorway. Walk across to the far right and enter that door. Go down the stairs over to the cell and talk to Wally. Head back up the stairs and through the door. Read the spit encrusted paper (in your inventory) and note the first verse. Find the collection of bones that matches the verse and push them. Walk through the door and read the next verse. Keep doing this until you find a huge door with heaps of locks. Open the door (simple, hey?) and pick up the key. You will, of course, be captured.
Ask LeChuck some stupid questions and he will leave. Ask Wally some questions too. Use the crazy straw with the green drink again. Spit at the shield to the right four times to extinguish the candle. When the room goes dark, use your matches. Boom.
You arrive on Dinky Island. Pit up the bottle that's floating in the water, and smash it on the rock. Pick up the martini glass and crowbar, and open the barrel near the parrot. Give the cracker to the parrot for your first clue. Fill the martini glass with sea water and then distill it using the still. Talk to Herman, then enter the jungle through the opening to the left.
In the jungle you should see two paths. Go to the left, and follow that path to the top of the next screen. Cut the hanging bag open with the broken bottle, and pick up the box of cracker mix. Follow the path back to the start of the jungle, and take the other path (northward). Pick up the rope and open the box with the crowbar. Take the dynamite, and head east for two screens, to find the dinosaur, where the bird will arrive. Give it another cracker for a second clue. Head north until you reach the rock pile, and give the parrot the last cracker. Follow the third hint by walking east, where you'll meet Herman. Use his shortcut to go back to the Big X, and dig a hole. Light the dynamite, and then throw it in the hole. Boom again.
After the cut-scene, attach the crow bar to the rope, and then use it with the twisted rods at the top of the hole. At the bottom of the hole, find a light switch, and talk to LeChuck. Walk to the far left and pick up the ticket from the smashed up treasure chest. Walk right all the way through the tunnel to the very far right hand end of the tunnel, and enter the first aid room. Look at the skeletons and pick up your dad's skull. Get the surgical gloves out of the trash can and the syringe out of the drawer.
Go to the storage room (through the doorway to the left of the first aid sign). Open the boxes to find a balloon, rootbeer and a voodoo doll. Head to the room with a doorway next to an elevator sign, and go through that doorway. Use the gloves and balloon with the helium container. Use the coin return to get a coin to pop out onto the floor. When LeChuck comes in and bends over to pick it up, steal his underwear. Return to this room after you get zapped away and pop out another coin. This time when he comes in, give him the hankie and he will blow his nose on it. Go inside the elevator, and wait for LeChuck. When he arrives, use the lever quickly, and cut his beard off.
Get out of the elevator and put the doll, beard, skull, hankie and underwear into the juju bag. Go back downstairs and find LeChuck. When you see him, use the syringe on the doll. Chase after him, and talk to him. Pull his mask off to end the game.